Ashley Marie Leonard
Kambo secretions after reconstituted with distilled water.
What is Kambo?
“If you understand peptides, you understand Kambo.” -Jason Fellows Tribal Detox Founder
The benefits of Kambo stem from the bioactive peptides and neuropeptides found in the Kambo secretion. (Amazonian giant waxy tree frog, Phyllomedusa Bicolor.) The bioactive peptides found in Kambo exert a positive effect in humans due to their health-promoting properties. They can exert several beneficial effects like preventing diseases or modulating the physiological systems once they are absorbed in the human body. These peptides perform a broad range of functions that can be involved in the gastrointestinal system such as the anti-obesity and satiety peptides, the cardiovascular system such as antihypertensive, antithrombotic, and hypocholesterolemic peptides, the immune system such as antimicrobial, and immune-modulatory peptides, and the nervous system such as opioid peptides.
All over the internet, podcasts, and sometimes word of mouth, Kambo is referred to as frog poison. This is not at all the case. In fact, while the secretions do have toxic effects for any would-be natural predator of the frog in the Amazon, the amazing cocktail of bioactive peptides contained in the sticky substance each play integral roles in the health and wellbeing of human biology AND are endogenous to the human body! Below lists some of the bioactive peptides present in Kambo which have been identified through scientific research:
Phyllomedusin
Produces smooth muscle contractions and increases secretions of the gastrointestinal tract. This contributes to the deep purge.
Phyllokinin
Potent vasodilators also increase the permeability of the blood-brain barrier.
Caeruleins/Sauvagines
Produces smooth muscle contractions as well as a drop in blood pressure and tachycardia. These peptides stimulate the adrenal cortex and pituitary gland and also possess analgesic properties.
Dermorphin/Deltorphin
Agonists of the opioid receptors, these peptides are 4000 times more potent than morphine and 40 times more potent than the endogenous endorphins.
Adenoregulins
Works on the human body through the adenosine receptors which are a fundamental component throughout all human cellular fuel.
Dermaseptins
Antimicrobial peptides are the frog’s first line of defense for the frog’s bare skin against microbial invasion. Separate research carried out at the University of Paris and Queens University in Belfast have shown that dermaseptins may have applications in treating certain types of cancer cells.
Bombesins
Stimulate pancreatic secretions and also stimulate the secretion of hydrochloric acid by acting on the G cells of the stomach.
Tryptophilins
Opening new perspectives on the human brain works.